Acetaminophen: Teen Asthma Trigger?
Aug. 13, 2010 -- Even once-a-month use of acetaminophen -- the best-known brand name is Tylenol -- may trigger asthma in teens.
Teens using acetaminophen at least monthly had 2.5 times the asthma risk of nonusers. Once-a-year users had a 43% increase in asthma risk.
The findings come from a study of some 323,000 13- and 14-year-olds from 50 nations by Richard W. Beasley, MD, professor of medicine at the Medical Research Institute of New Zealand in Wellington, and colleagues.
The current study is the first to link acetaminophen use to teen asthma. The Beasley team is among a number of research groups that over the last decade have accumulated evidence that acetaminophen increases asthma risk.
But the studies do not prove that acetaminophen causes asthma. It could simply be that children and pregnant women at risk of asthma are more likely to take acetaminophen.
Beasley and colleagues say it's time to find out for sure. They calculate that acetaminophen use may explain some 30% of child asthma and some 40% of teen asthma.
"Randomized, controlled trials are now urgently required to investigate this relationship further and to guide the use of [fever-reducing drugs], not only in children but also in pregnancy and adult life," they conclude in their report.
Allergist Clifford Bassett, MD, of New York University's Langone Medical Center, agrees. Bassett was not involved in the Beasley study.
"There is an urgent need for clinical trials," Bassett tells WebMD.
Slideshow: Anatomy of an Asthma Attack
Teens using acetaminophen at least monthly had 2.5 times the asthma risk of nonusers. Once-a-year users had a 43% increase in asthma risk.
The findings come from a study of some 323,000 13- and 14-year-olds from 50 nations by Richard W. Beasley, MD, professor of medicine at the Medical Research Institute of New Zealand in Wellington, and colleagues.
The current study is the first to link acetaminophen use to teen asthma. The Beasley team is among a number of research groups that over the last decade have accumulated evidence that acetaminophen increases asthma risk.
But the studies do not prove that acetaminophen causes asthma. It could simply be that children and pregnant women at risk of asthma are more likely to take acetaminophen.
Beasley and colleagues say it's time to find out for sure. They calculate that acetaminophen use may explain some 30% of child asthma and some 40% of teen asthma.
"Randomized, controlled trials are now urgently required to investigate this relationship further and to guide the use of [fever-reducing drugs], not only in children but also in pregnancy and adult life," they conclude in their report.
Allergist Clifford Bassett, MD, of New York University's Langone Medical Center, agrees. Bassett was not involved in the Beasley study.
"There is an urgent need for clinical trials," Bassett tells WebMD.
Slideshow: Anatomy of an Asthma Attack
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