Aortic Reservoir Characteristics and Brain Structure in T2DM
In summary, this is the first study to examine associations between aortic reservoir characteristics and brain structure. Our findings suggest that Pexcess may be an important contributor to brain atrophy in healthily ageing individuals whereas in patients with T2DM, aortic stiffening may play a more prominent role. These findings suggest that there may be different vascular abnormalities contributing to brain dysfunction among diabetics compared with non-diabetics. However more work is required to determine the underlying central vascular mechanism/s.
Conclusions
In summary, this is the first study to examine associations between aortic reservoir characteristics and brain structure. Our findings suggest that Pexcess may be an important contributor to brain atrophy in healthily ageing individuals whereas in patients with T2DM, aortic stiffening may play a more prominent role. These findings suggest that there may be different vascular abnormalities contributing to brain dysfunction among diabetics compared with non-diabetics. However more work is required to determine the underlying central vascular mechanism/s.
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