GFR and Albuminuria Predict Mortality: Diabetes Heart Study
This study was an extension of our prior observations of independent relationships between albuminuria and CAC, and between CAC and mortality, and examined whether indices of kidney disease were predictive of mortality in EAs with T2D after considering the risk conferred by the presence of subclinical CVD. These results provide further support for the utility of routine clinical indices of kidney function and proteinuria in the prediction of mortality, independent from subclinical CVD and in the absence of more direct measures of CVD burden. As UACR is a modifiable risk factor and treatments exist for slowing the rate of eGFR decline, this information is clinically useful for risk stratification along with management of traditional CVD risk factors in EA T2D-affected individuals.
Conclusions
This study was an extension of our prior observations of independent relationships between albuminuria and CAC, and between CAC and mortality, and examined whether indices of kidney disease were predictive of mortality in EAs with T2D after considering the risk conferred by the presence of subclinical CVD. These results provide further support for the utility of routine clinical indices of kidney function and proteinuria in the prediction of mortality, independent from subclinical CVD and in the absence of more direct measures of CVD burden. As UACR is a modifiable risk factor and treatments exist for slowing the rate of eGFR decline, this information is clinically useful for risk stratification along with management of traditional CVD risk factors in EA T2D-affected individuals.
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