Immune Restoration Disease in HIV Patient
We describe a severely immunosuppressed HIV-1-positive man in whom immune restoration disease associated with pulmonary infection caused by Mycobacterium microti developed after antiretroviral treatment. The diagnosis was made by using convenient spoligotyping techniques, but invasive investigations were required to exclude a tumor.
During the first few months of highly active antiretroviral treatment, immune restoration may be complicated by clinical events in which either previously subclinical infections are found or preexisting partially treated opportunistic infections deteriorate. This condition, termed immune restoration disease (IRD), is thought to be caused by the improvement in the host's immune response to pathogens. We report what we believe is the first recorded case of IRD with confirmed Mycobacterium microti infection. M. microti is an unusual infection associated with small rodents. Novel genetic techniques have confirmed it as a human pathogen, but its true incidence remains unclear.
We describe a severely immunosuppressed HIV-1-positive man in whom immune restoration disease associated with pulmonary infection caused by Mycobacterium microti developed after antiretroviral treatment. The diagnosis was made by using convenient spoligotyping techniques, but invasive investigations were required to exclude a tumor.
During the first few months of highly active antiretroviral treatment, immune restoration may be complicated by clinical events in which either previously subclinical infections are found or preexisting partially treated opportunistic infections deteriorate. This condition, termed immune restoration disease (IRD), is thought to be caused by the improvement in the host's immune response to pathogens. We report what we believe is the first recorded case of IRD with confirmed Mycobacterium microti infection. M. microti is an unusual infection associated with small rodents. Novel genetic techniques have confirmed it as a human pathogen, but its true incidence remains unclear.
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