Natural History of Colonization With MRSA and VRE
Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) are endemic in hospital settings and long-term care facilities (LTCF), and the prevalence of colonization is increasing. The growing pools of colonized, and therefore isolated patients, impact patient care and burden the healthcare system. The duration of MRSA and VRE colonization has previously been assessed in mostly small studies. Thus, pooling of these data might provide a better understanding of the natural history of colonization and the timing of clearance and thereby inform clinical care and public policy. We performed a systematic review of randomized controlled trials and observational studies that followed patients with a history of MRSA and VRE colonization and assessed study characteristics and study quality. In the absence of individual data, we pooled study-level data to calculate estimates of time to clearance of colonization.
Background
Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) are endemic in hospital settings and long-term care facilities (LTCF), and the prevalence of colonization is increasing. The growing pools of colonized, and therefore isolated patients, impact patient care and burden the healthcare system. The duration of MRSA and VRE colonization has previously been assessed in mostly small studies. Thus, pooling of these data might provide a better understanding of the natural history of colonization and the timing of clearance and thereby inform clinical care and public policy. We performed a systematic review of randomized controlled trials and observational studies that followed patients with a history of MRSA and VRE colonization and assessed study characteristics and study quality. In the absence of individual data, we pooled study-level data to calculate estimates of time to clearance of colonization.
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