PRP Systems Vary Widely in Effective Wound Healing
Sundman EA, Cole BJ, Fortier LA
Am J Sports Med. 2011 Aug 16.
Platelet-rich plasma (PRP) has been increasingly used as a method to enhance tissue healing. PRP is thought to promote healing by concentrating growth factors naturally found in platelet cells in the blood at the injury site. However, PRP contains both anabolic factors derived from platelets as well as catabolic factors produced by leukocytes in the mixture, and these concentrations can vary across commercial PRP preparation systems. In this in vitro study, researchers measured anabolic growth factors from platelets (tumor growth factor-b1 and platelet-derived growth factor-AB) and catabolic cytokines from leukocytes (matrix metalloproteinase-9 and interleukin-1b) as well as platelet:leukocyte concentrations from each PRP sample derived from either the Arthrex ACP® Double Syringe System or the Biomet GPS® III Mini Platelet Concentrate System.
The Arthrex samples consisted of 1.99x concentrated platelets and 0.13x diminished leukocytes compared with whole blood. The Biomet samples were found to have 4.69x concentrated platelets and 4.26x leukocytes compared with whole blood. Anabolic growth factors were found to be significantly higher in the Biomet sample, as were catabolic cytokine factors. Positive correlations were found between growth factors and platelets as well as between catabolic factors and leukocytes.
The significantly increased use of PRP in recent years has led to a dramatic increase in the number of commercial PRP systems. The investigators in this article bring attention to an interesting issue of variability in PRP preparation and content. Further investigational studies should focus on the clinical implications of this study's in vitro results, particularly given the fact that there are now more than 15 different PRP systems that are commercially available.
Abstract
PRP Systems Vary Widely in Effective Wound Healing
Sundman EA, Cole BJ, Fortier LA
Am J Sports Med. 2011 Aug 16.
Study Summary
Platelet-rich plasma (PRP) has been increasingly used as a method to enhance tissue healing. PRP is thought to promote healing by concentrating growth factors naturally found in platelet cells in the blood at the injury site. However, PRP contains both anabolic factors derived from platelets as well as catabolic factors produced by leukocytes in the mixture, and these concentrations can vary across commercial PRP preparation systems. In this in vitro study, researchers measured anabolic growth factors from platelets (tumor growth factor-b1 and platelet-derived growth factor-AB) and catabolic cytokines from leukocytes (matrix metalloproteinase-9 and interleukin-1b) as well as platelet:leukocyte concentrations from each PRP sample derived from either the Arthrex ACP® Double Syringe System or the Biomet GPS® III Mini Platelet Concentrate System.
The Arthrex samples consisted of 1.99x concentrated platelets and 0.13x diminished leukocytes compared with whole blood. The Biomet samples were found to have 4.69x concentrated platelets and 4.26x leukocytes compared with whole blood. Anabolic growth factors were found to be significantly higher in the Biomet sample, as were catabolic cytokine factors. Positive correlations were found between growth factors and platelets as well as between catabolic factors and leukocytes.
Viewpoint
The significantly increased use of PRP in recent years has led to a dramatic increase in the number of commercial PRP systems. The investigators in this article bring attention to an interesting issue of variability in PRP preparation and content. Further investigational studies should focus on the clinical implications of this study's in vitro results, particularly given the fact that there are now more than 15 different PRP systems that are commercially available.
Abstract
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