The Effect and Safety of Autologous Cultured Osteoblast Injection
Background: We performed a multicenter, open, randomized, clinical study of autologous cultured osteoblast injection for long-bone fracture, to evaluate the fracture healing acceleration effect and the safety of autologous cultured osteoblasts.
Methods: Sixty-four patients with long-bone fractures were randomly divided into two groups, i.e. those who received autologous cultured osteoblast injection and those who received no treatment. The sum of the difference in the callus formation scores after four and eight weeks, was used as the first efficacy variable.
Results: The autologous cultured osteoblast injection group showed fracture healing acceleration of statistical significance, and there were no specific patient complications when using this treatment.
Conclusion: Autologous cultured osteoblast injection should therefore be considered as a successful treatment option for treating long-bone fracture.
Trial Registration: Current Controlled Trials ISRCTN10637905.
During the past few decades, various surgical instruments and external as well as internal metal fixators have been developed for the treatment of fractures; these instruments are constantly being improved in order to provide more effective fracture treatment. To accelerate fracture healing, ultrasound and other treatment methods have also recently been introduced. In particular, cell therapy suggests a new treatment approach. For articular cartilage defects, autologous chondrocyte implantation has become the major treatment, and even as a treatment for fracture, the use of autologous cultured osteoblasts has been suggested.
When using bone grafts, problems may develop in the donor area in general autologous bone grafts and immunological problems, while the spread of disease may also develop in allografts. There may be faster patient recovery and an absence of these problems when autologous cultured osteoblasts are used. However, as there are only a small number of cells within bone marrow which can be differentiated into osteoblasts, cell culture is essential for clinical applications. Therefore, it can be anticipated that osteoblasts obtained using cell culture methods may be helpful for healing fractures.
Kim et al. showed in animal studies that transplanted autologous cultured osteoblasts induced osteogenesis in bone defect areas. Our current study was conducted to determine whether autologous cultured osteoblasts injected at fracture sites could accelerate the fracture-healing process.
Abstract and Background
Abstract
Background: We performed a multicenter, open, randomized, clinical study of autologous cultured osteoblast injection for long-bone fracture, to evaluate the fracture healing acceleration effect and the safety of autologous cultured osteoblasts.
Methods: Sixty-four patients with long-bone fractures were randomly divided into two groups, i.e. those who received autologous cultured osteoblast injection and those who received no treatment. The sum of the difference in the callus formation scores after four and eight weeks, was used as the first efficacy variable.
Results: The autologous cultured osteoblast injection group showed fracture healing acceleration of statistical significance, and there were no specific patient complications when using this treatment.
Conclusion: Autologous cultured osteoblast injection should therefore be considered as a successful treatment option for treating long-bone fracture.
Trial Registration: Current Controlled Trials ISRCTN10637905.
Background
During the past few decades, various surgical instruments and external as well as internal metal fixators have been developed for the treatment of fractures; these instruments are constantly being improved in order to provide more effective fracture treatment. To accelerate fracture healing, ultrasound and other treatment methods have also recently been introduced. In particular, cell therapy suggests a new treatment approach. For articular cartilage defects, autologous chondrocyte implantation has become the major treatment, and even as a treatment for fracture, the use of autologous cultured osteoblasts has been suggested.
When using bone grafts, problems may develop in the donor area in general autologous bone grafts and immunological problems, while the spread of disease may also develop in allografts. There may be faster patient recovery and an absence of these problems when autologous cultured osteoblasts are used. However, as there are only a small number of cells within bone marrow which can be differentiated into osteoblasts, cell culture is essential for clinical applications. Therefore, it can be anticipated that osteoblasts obtained using cell culture methods may be helpful for healing fractures.
Kim et al. showed in animal studies that transplanted autologous cultured osteoblasts induced osteogenesis in bone defect areas. Our current study was conducted to determine whether autologous cultured osteoblasts injected at fracture sites could accelerate the fracture-healing process.
SHARE
