First Reports of Adverse Drug Reactions
The following table contains an overview of first published case reports of adverse drug reactions identified in the international literature in recent weeks. Any claim to a 'first report' is verified by a database search of previous literature.
Serious: an event is serious (FDA MedWatch definition) when the patient outcome is death, life-threatening, hospitalisation, disability, congenital anomaly, or requires intervention to prevent permanent impairment or damage.
The following table contains an overview of first published case reports of adverse drug reactions identified in the international literature in recent weeks. Any claim to a 'first report' is verified by a database search of previous literature.
| Drug and ADR | Reference |
|---|---|
| Baclofen/citalopram/doxepin: interaction with methadone or hydromorphone leading to myositis | Veghis A, McKee Jr AL, Steinberg RB. Myositis associated with opioid and anti-depressant treatment of chronic pain [abstract]. J Pain 2001 Apr; 2 (Suppl. 1): 43 |
| Clozapine: interaction with concomitant nefazodone leading to hypotension, anxiety and dizziness | Khan AY, Preskorn SH. Increase in plasma levels of clozapine and norclozapine after administration of nefazodone. J Clin Psych 2001 May; 62: 375-6 |
| Erythromycin: interaction with concomitant sirolimus leading to increased sirolimus concentration | Claesson K, Brattström C, Burke JT. Sirolimus and erythromycin interaction: two cases. Transplant Proc 2001 May; 33: 2136 |
| Interferon-ß: congenital disorders in an infant (serious) | Watanabe M, Kohge N, Akagi S, et al. Congenital anomalies in a child born from a mother with interferon-treated chronic hepatitis B. Am J Gastro 2001 May; 96: 1668-9 |
| Mirtazapine: palinopsia | Ihde-Scholl T, Jefferson JW. Mirtazapine-associated palinopsia. J Clin Psych 2001 May; 62: 373 |
| Rofecoxib: gastrointestinal haemorrhage (serious) | Caroli A, Moica F. Severe upper gastrointestinal bleeding during treatment with rofecoxib for osteoarthritis. Am J Gastro 2001 May; 96: 1663-5 |
| Teicoplanin: exanthematous pustulosis in an elderly patient | Chu C-Y, Wu J, Jean S-S, et al. Acute generalized exanthematous pustulosis due to teicoplanin. Dermatology 2001; 202 (2): 141-2 |
| Thiamazole: exacerbation of asthma in an elderly patient (serious) | Grembiale RD, Naty S, Iorio C, et al. Bronchial asthma induced by an antithyroid drug. Chest 2001 May; 119: 1598-9 |
Serious: an event is serious (FDA MedWatch definition) when the patient outcome is death, life-threatening, hospitalisation, disability, congenital anomaly, or requires intervention to prevent permanent impairment or damage.
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