Vince Vaughn follows up his hugely successful romantic comedy Wedding Crashers with what's best described as an anti-romantic comedy. Vaughn's latest film, The Break-Up, takes the classic romantic comedy set-up and twists it on its head.

The title pretty much sums up the film's plot. The Break-Up zooms through the 'boy meets girl' part to focus more on the stress, strain and general uncomfortableness associated with the end of a relationship.

The Inspiration for The Break-Up: ?Whenever I got scripts for romantic comedies, they always had some kind of bizarre subplot to them that really didn't have anything to do with relationships. Like, 'If you don't marry the girl, you will not inherit the family fortune and the mean guy who works for me will take over the company.' Or, 'I have to write an article for the paper... Oops, I really did fall in love with the girl, what do I do?' And I always just felt relationships were kind of odd enough as they are.

It's an idea I had 10 years ago. I love the movie The Odd Couple, and I always liked that movie, and as I got older I realized a lot of people were sort of buying places together because they didn't want to just spend money on rent. They wanted to have ownership and get much more kind of savvy with making their money work for them. I had some friends who ended up in that position, where they no longer wanted to date the other person and were not married, but no one could afford the place on their own, so it seems kind of modern in that.?

Vaughn continued. ?And then it wasn't so much based in particularly any sort of one relationship I had, but there's elements of relationships that I had. I thought that there was stuff that was very universal about not remembering to bring home 12 lemons and having the argument be about the lemons, but really the argument being about so much more than the lemons, but that just sort of being the vehicle to discuss stuff.?

Going Against the Grain: Vaughn?s now starred in a couple of against-the-norm comedies that have done well. So why don?t more people copy his formula for success and attempt something a little different? Vaughn answered, ?I don't know. I think there's room for everything. It's just my sensibilities, sort of starting with Swingers. I like stuff that's kind of character-driven, exaggerated for comedy. Like the scene in Swingers where he calls five times and leaves that message. It's funny, but it's also really painful. And I liked in this movie, that you sort of look at the male-female drama and laugh at it, and then you kind of have a more serious complicated side that's more truthful in it.

You can only, sort of, for me, do stuff that you're interested in or that you find to be kind of fascinating or interesting. You certainly don't - like with Wedding Crashers or this -- approach it saying, 'I want to be different just for being different.' You just try to put original thought into it and say, 'What's simple and truthful for this story even if it's not traditional?' So I don't really go into any of them going, 'What's a way to do this totally different?' I more go into it saying, 'What's an original way of doing it,' if that makes sense??

Casting Jennifer Aniston and the Chemistry Onscreen: ?You know, when we were developing the screenplay, she was the only actor that I had in mind because she's so good with comedy. She's also a very good actor and she also has a quality to her that just inherently she's very likeable. There's a warmth to Jennifer. These characters are both very flawed, so it's important to have that.

When we started the rehearsal process, right away I really was impressed with her acting, her timing, with all of that. Unfortunately a lot of time it's like women are stuck in movies just sort of rolling their eyes at whatever the guy does. One thing that I really liked and that me and David [Dobkin] really insisted on in Wedding Crashers, is Isla [Fisher's] really funny in that movie, too. It's really both of us, and the scenes become funny. I like the comedy to come out of the situation, be grounded in reality, so Jennifer is really the heart of the movie, like Owen is the heart of the movie in Crashers. [She can be a straight man, as it would be, in this movie, and then also able to be comedic if it calls for it, but never lose that sense of being real and being a real person taking this journey. The whole movie would falter, so she was really instrumental. And yes, I did like her right off the back as a person as well. I think she's terrific.?

Page 2:The Real Vince Vaughn Compared to His Break-Up Character