Modern Management of Ocular Surface Squamous Neoplasia
The isolation of the factors for more aggressive OSSN will allow more tailored approaches to patient management. Factors such as tarsal involvement, positive pathological margins and a higher pathological tumor grade have all been implicated in disease recurrence. Dysplasia, carcinoma in situ and aggressive squamous ocular surface carcinoma may not have distinguishable clinical features. Therefore, any suspicious ocular surface lesions should be treated as invasive squamous carcinoma. Regarding patient factors that can influence disease severity, Lee et al. found that ocular irritation as the presenting complaint of OSSN is associated with a 2.4-fold increase in recurrence after treatment compared with the patients that did not present with this complaint. Furthermore, patient factors such as xeroderma pigmentosa and HIV infection may increase the severity of disease.
Prognosis
The isolation of the factors for more aggressive OSSN will allow more tailored approaches to patient management. Factors such as tarsal involvement, positive pathological margins and a higher pathological tumor grade have all been implicated in disease recurrence. Dysplasia, carcinoma in situ and aggressive squamous ocular surface carcinoma may not have distinguishable clinical features. Therefore, any suspicious ocular surface lesions should be treated as invasive squamous carcinoma. Regarding patient factors that can influence disease severity, Lee et al. found that ocular irritation as the presenting complaint of OSSN is associated with a 2.4-fold increase in recurrence after treatment compared with the patients that did not present with this complaint. Furthermore, patient factors such as xeroderma pigmentosa and HIV infection may increase the severity of disease.
SHARE
